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Red Bull have shown that they are the team to beat again this year, with back-to-back one-two finishes in Bahrain and Saudi Arabia, with defending champion Max Verstappen winning the opening race while Sergio Perez took victory on Sunday.
"What Lewis has achieved in F1 is second to none," said Horner, "but we're very happy with the drivers that we have.
"They're committed as a pair not only this season but the next season as well. So, I can't see where we would be able to accommodate Lewis."
Despite their relatively poor start to the season, which leaves them third in the constructors' championship, Horner went on to predict a resurgent Mercedes and Hamilton.