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Southgate is certainly not alone in having to adapt to key withdrawals this international break.
Wales boss Rob Page has spoken of his anger that Brennan Johnson was able to play for Nottingham Forest, but two days later went on to be unavailable for Wales because of fitness concerns.
"We were aware of something last week and then he went and played 90 minutes on the Friday and wasn't available to meet up on the Sunday," said Page. "Everybody's responsible for him. It's very special to be in that changing room and play for your country."